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original article |
Date |
Title |
Authors All Authors |
| 1 |
[GO] |
2026―Mar―11 |
Biocatalytic Oxidative Desymmetrization of the Substituted Pyrrolidine Intermediate of MK-7845: An Investigational Antiviral Therapy for COVID-19 |
Shorouk O. Badir, Yangzhong Qin, Michelle Zheng, David A. Vargas, Birgit Kosjek, Ajit Vikram, et al. (+11) Anna L. Dunn, Michael Whittington, Yining Ji, Keith A. Mattern, Alex M. Confer, Jonathan M. E. Hughes, Reed T. Larson, Justin A. Newman, Nastaran Salehi Marzijarani, Nadine Kuhl, Jamie M. McCabe Dunn |
| 2 |
[GO] |
2025―Feb―25 |
Development of a Scalable Manufacturing Process for AB-343 Drug Substance: A Potential Candidate for the Treatment of Coronavirus Infections |
Jeremy D. Mason, Jan M. Spink, Mahesh Pallerla, Zhenhua Wu, Rajeev K. Singh, Aravind B. Pulipaka, et al. (+5) Jia Liu, Marvin Marcus Vega, Xu Wang, Michael J. Sofia, Ganapati Reddy Pamulapati |
| 3 |
[GO] |
2024―Jun―06 |
Rapid End-Game Process Development and First GMP Production of MK-7845: An Experimental Antiviral Treatment for COVID-19 |
Nicholas R. Deprez, Jonathan M. E. Hughes, Shorouk O. Badir, Stasik Popov, Teresa Andreani, Rachel S. Bade, et al. (+23) Clara Hartmanshenn, Thomas Tai-min Kwok, Donald R. Gauthier, Nastaran Salehi Marzijarani, Zeinab Sakhaei, Riki Drout, Steve Castro, David J. Schenk, Charles Wolstenholme, Nilusha Padivitage, Cody Welch, Jason R. Kowalski, Brittany Kassim, Yong Liu, Ryan D. Cohen, Alex M. Confer, Guilherme Dal Poggetto, Andrew P. J. Brunskill, Feng Peng, Ji Qi, Jing Xu, Mingxiang Lin, Jamie M. McCabe Dunn |
| 4 |
[GO] |
2024―May―17 |
Early Kilogram Scale Delivery of MK-7845 as a Potential COVID-19 Therapy: Rapid Process Development of Key Intermediates |
Feng Peng, Ji Qi, Jin Zhang, Enkai Wang, Xiaohui Cao, Lu Chen, et al. (+11) Chao Fan, Wei Fan, Cheng Feng, Mingxiang Lin, Mingjie Liu, Christopher C. Nawrat, Danielle M. Schultz, Chaohui Song, Feng Wang, Jingjun Yin, Yuming Zhang |
| 5 |
[GO] |
2023―Nov―20 |
Optimized Kilogram-Scale Synthesis and Impurity Identification of SHEN26 (ATV014) for Treating COVID-19 |
Qishu Chen, Qifan Zhou, Guanguan Li, Shuo Li, Yingjun Li, Xumu Zhang |
| 6 |
[GO] |
2023―Oct―20 |
Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19 |
Rachel Bade, Jameson R. Bothe, Eric Sirota, Andrew P. J. Brunskill, Justin A. Newman, Yongqian Zhang, et al. (+22) Melissa Tan, Michelle Zheng, Gilmar Brito, Marc Poirier, Patrick S. Fier, Yingju Xu, Michael D. Ward, Kevin Stone, Ivan H. Lee, Andrew J. Gmitter, Frank Bernardoni, Michael A. Zompa, Hanlin Luo, Sanjaykumar Patel, Tina Masiuk, Jeff Mora, Tong Ni, Grace A. Okoh, James Tarabokija, Jiaying Liu, Michael B. Lowinger, Tariq Mahmood |
| 7 |
[GO] |
2023―Jun―23 |
Correction to “Toward a Practical, Nonenzymatic Process for Investigational COVID-19 Antiviral Molnupiravir from Cytidine: Supply-Centered Synthesis” |
Vijayagopal Gopalsamuthiram, Appasaheb L. Kadam, Jeffrey M. Noble, David R. Snead, Corshai Williams, Timothy F. Jamison, et al. (+10) Chris Senanayake, Ajay K. Yadaw, Sarabindu Roy, Gopal Sirasani, B. Frank Gupton, Justina Burns, Daniel W. Cook, Rodger W. Stringham, Saeed Ahmad, Rudy Krack |
| 8 |
[GO] |
2023―Feb―03 |
Early Clinical Development of Lufotrelvir as a Potential Therapy for COVID-19 |
Christophe Allais, David Bernhardson, Adam R. Brown, Gary M. Chinigo, Jean-Nicolas Desrosiers, Kenneth J. DiRico, et al. (+18) Ian Hotham, Brian P. Jones, Samir A. Kulkarni, Chad A. Lewis, Ricardo Lira, Richard P. Loach, Peter D. Morse, James J. Mousseau, Matthew A. Perry, Zhihui Peng, David W. Place, Anil M. Rane, Lacey Samp, Robert A. Singer, Zheng Wang, Gerald A. Weisenburger, Hatice G. Yayla, Joseph M. Zanghi |
| 9 |
[GO] |
2021―Dec―10 |
Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19 |
Patrick S. Fier, Yingju Xu, Marc Poirier, Gilmar Brito, Michelle Zheng, Rachel Bade, et al. (+22) Eric Sirota, Kevin Stone, Lushi Tan, Guy R. Humphrey, Darryl Chang, Jameson Bothe, Yongqian Zhang, Frank Bernardoni, Steve Castro, Michael A. Zompa, Jerry Taylor, Kevin M. Sirk, Anthony Diaz-Santana, Ike Diribe, Khateeta M. Emerson, Bharath Krishnamurthi, Ralph Zhao, Michael Ward, Chengqian Xiao, Honggui Ouyand, Jianfeng Zhan, William J. Morris |
| 10 |
[GO] |
2021―Dec―09 |
Toward a Practical, Nonenzymatic Process for Investigational COVID-19 Antiviral Molnupiravir from Cytidine: Supply-Centered Synthesis |
Vijayagopal Gopalsamuthiram, Appasaheb L. Kadam, Jeffrey K. Noble, David R. Snead, Corshai Williams, Timothy F. Jamison, et al. (+10) Chris Senanayake, Ajay K. Yadaw, Sarabindu Roy, Gopal Sirasani, B. Frank Gupton, Justina Burns, Daniel W. Cook, Rodger W. Stringham, Saeed Ahmad, Rudy Krack |
| 11 |
[GO] |
2021―Apr―19 |
Quest for a Cure: Potential Small-Molecule Treatments for COVID-19, Part 2 |
David L. Hughes |
| 12 |
[GO] |
2020―Jun―02 |
Quest for a COVID-19 Cure by Repurposing Small Molecule Drugs: Mechanism of Action, Clinical Development, Synthesis at Scale, and Outlook for Supply |
Chris De Savi, David L Hughes, Lisbet Kvaerno |
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