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original article |
Date |
Title |
Authors All Authors |
1 |
[GO] |
2025―May―23 |
Tipranavir analogs as antiviral agents: Design, synthesis, in vitro, and in silico study of new SARS-CoV-2 main protease inhibitors |
Selwan M. El-Sayed, Dina I.A. Othman, Ghada S. Hassan, Ahmed H.E. Hassan, Shahenda M. El-Messery, Ahmed R. El-Sheakh |
2 |
[GO] |
2025―Apr―05 |
Synthesis of new selective agents with dual anti-inflammatory and SARS-CoV-2 Mpro inhibitory activity: Antipyrine-celecoxib hybrid analogues; COX-2, COVID-19 cytokine storm and replication inhibitory activities. |
Eman K.A. Abdelall, Heba A.H. Elshemy, Madlen B. Labib, John N. Philoppes, Fares E.M. Ali, Amira K.M. Ahmed |
3 |
[GO] |
2024―Dec―24 |
Buckyballs to fight pandemic: Water-soluble fullerene derivatives with pendant carboxylic groups emerge as a new family of promising SARS-CoV-2 inhibitors |
Olga A. Kraevaya, Valeriya S. Bolshakova, Alexander V. Slita, Iana L. Esaulkova, Alexander V. Zhilenkov, Mikhail G. Mikhalsky, et al. (+6) Ekaterina O. Sinegubova, Ilya I. Voronov, Alexander S. Peregudov, Alexander F. Shestakov, Vladimir V. Zarubaev, Pavel A. Troshin |
4 |
[GO] |
2024―Nov―22 |
A Glimpse for the subsistence from pandemic SARS-CoV-2 infection |
Santosh K. Rath, Ashutosh K. Dash, Nandan Sarkar, Mitali Panchpuri |
5 |
[GO] |
2024―Nov―19 |
Design, synthesis, and biological evaluation of novel AAK1/HDACs dual inhibitors against SARS-CoV-2 entry |
Nian-Dong Mao, Yueying Xu, Xia Yao, Yuan Gao, Zi Hui, Hao Che, et al. (+6) Chenchen Wang, Jinshan Lu, Jie Yu, Suwen Hu, Hang Zhang, Xiang-Yang Ye |
6 |
[GO] |
2024―Oct―28 |
Design, synthesis, and structure-activity relationships of xanthine derivatives as broad-spectrum inhibitors of coronavirus replication |
Xiaofang Chen, Xiaotian Ding, Cong Bian, Kun Wang, Xiao Zheng, Haiyan Yan, et al. (+8) Mengqian Qiao, Shuo Wu, Yihua Li, Li Wang, Lifei Wang, Yu Du, Yuhuan Li, Bin Hong |
7 |
[GO] |
2024―Oct―18 |
Identification of adenosine analogues as nsp14 N7-methyltransferase inhibitors for treating coronaviruses infection |
Qishu Chen, Qifan Zhou, Sidi Yang, Fan Pan, Hongqi Tao, Yuanmei Wen, et al. (+6) Yang Chao, Cailing Xie, Weixin Ou, Deying Guo, Yingjun Li, Xumu Zhang |
8 |
[GO] |
2024―Jun―28 |
Density functional theory and enzyme studies support interactions between angiotensin receptor blockers and angiotensin converting enzyme-2: Relevance to coronavirus 2019 |
Vasso Apostolopoulos, Nikitas Georgiou, Demeter Tzeli, Thomas Mavromoustakos, Graham J. Moore, Konstantinos Kelaidonis, et al. (+7) Minos-Timotheos Matsoukas, Sotirios Tsiodras, Jordan Swiderski, Laura Kate Gadanec, Anthony Zulli, Christos T. Chasapis, John M. Matsoukas |
9 |
[GO] |
2024―Apr―17 |
A path from synthesis to emergency use authorization of molnupiravir as a COVID-19 therapy |
Norein Sakander, Ajaz Ahmed, Mahir Bhardwaj, Diksha Kumari, Utpal Nandi, Debaraj Mukherjee |
10 |
[GO] |
2024―Apr―16 |
Non-peptidic inhibitors targeting SARS-CoV-2 main protease: A review |
Ya-Qi Xiao, Jiao Long, Shuang-Shuang Zhang, Yuan-Yuan Zhu, Shuang-Xi Gu |
11 |
[GO] |
2024―Mar―27 |
New meroterpenoids and polyketides from the endophytic fungus Paraphaeosphaeria sp. C-XB-J-1 and their anti-inflammatory and SARS-CoV-2 Mpro inhibitory activities |
Qi Li, Peng-Yun Yang, Chao Peng, Xing-Jie Zhang, Yun-Tao Jiang, Yan-Ping Li, Lu Gao |
12 |
[GO] |
2023―Dec―10 |
Enhancement efficiency delivery of antiviral Molnupiravir-drug via the loading with self-assembly nanoparticles of pycnogenol and cellulose which are decorated by zinc oxide nanoparticles for COVID-19 therapy |
Nagi M. El-Shafai, Yasser S. Mostafa, Mohamed S. Ramadan, Ibrahim El-Mehasseb |
13 |
[GO] |
2023―Dec―06 |
Discovery of α-Ketoamide inhibitors of SARS-CoV-2 main protease derived from quaternized P1 groups |
Qiao Huang, Baoxue Quan, Yan Chen, Xiu Zhao, Yanmei Zhou, Chong Huang, et al. (+6) Jingxin Qiao, Yifei Wang, Yueyue Li, Shengyong Yang, Jian Lei, Linli Li |
14 |
[GO] |
2023―Sep―30 |
Synthesis, docking studies and biological evaluation of 1H-1,2,3-triazole-7-chloroquinoline derivatives against SARS-CoV-2 |
Jerome P.L. Ng, Yun Xiao Yun, Ali Adnan Nasim, Alessandra Gianoncelli, Betty Yuan Kwan Law, Giovanni Ribaudo, et al. (+2) Vincent Kam Wai Wong, Paolo Coghi |
15 |
[GO] |
2023―Sep―05 |
Discovery of new non-covalent and covalent inhibitors targeting SARS-CoV-2 papain-like protease and main protease |
Wandong Liu, Juan Wang, Suyun Wang, Kairui Yue, Yu Hu, Xiaochun Liu, et al. (+3) Lihao Wang, Shengbiao Wan, Ximing Xu |
16 |
[GO] |
2023―Jan―28 |
Green and efficient one-pot three-component synthesis of novel drug-like furo[2,3-d]pyrimidines as potential active site inhibitors and putative allosteric hotspots modulators of both SARS-CoV-2 MPro and PLPro |
Hossein Mousavi, Behzad Zeynizadeh, Mehdi Rimaz |
17 |
[GO] |
2022―Nov―17 |
Exploring the dual effect of novel 1,4-diarylpyranopyrazoles as antiviral and anti-inflammatory for the management of SARS-CoV-2 and associated inflammatory symptoms |
Azizah M. Malebari, Hany E. A. Ahmed, Saleh K. Ihmaid, Abdelsattar M. Omar, Yosra A. Muhammad, Sultan S. Althagfan, et al. (+9) Naif Aljuhani, Abdel-Aziz A. A. El-Sayed, Ahmed H. Halawa, Heba M. El-Tahir, Safaa A. Turkistani, Mohammed Almaghrabi, Ahmed K. B. Aljohani, Ahmed M. El-Agrody, Hamada S. Abulkhair |
18 |
[GO] |
2022―Nov―09 |
Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses |
Ruyu Wang, Guanglei Zhai, Guanghao Zhu, Mengge Wang, Xiaoyi Gong, Weidong Zhang, et al. (+3) Guangbo Ge, Hongzhuan Chen, Lili Chen |
19 |
[GO] |
2022―Jun―26 |
Synthesis and Structure-Activity Relationship Study of Saponin-Based Membrane Fusion Inhibitors against SARS-CoV-2 |
Youngho Jang, Tai Young Kim, Sangeun Jeon, Hyeonggeun Lim, JinAh Lee, Seungtaek Kim, et al. (+2) C. Justin Lee, Sunkyu Han |
20 |
[GO] |
2022―May―04 |
Synthesis, antimicrobial, molecular docking and molecular dynamics studies of lauroyl thymidine analogs against SARS-CoV-2: POM study and identification of the pharmacophore sites |
Mohammed Anowar Hosen, Nasrin Sultana Munia, Mohammed Al-Ghorbani, Mohammed Baashen, Faisal A. Almalki, Taibi Ben Hadda, et al. (+5) Ferdausi Ali, Shafi Mahmud, Md. Abu Saleh, Hamid Laaroussi, Sarkar M.A. Kawsar |
21 |
[GO] |
2022―Apr―18 |
Hydroxamate and thiosemicarbazone: two highly promising scaffolds for the development of SARS-CoV-2 antivirals |
Yin-Sui Xu, Jia-Zhu Chigan, Jia-Qi Li, Huan-Huan Ding, Le-Yun Sun, Lu Liu, et al. (+2) Zhenxin Hu, Ke-Wu Yang |
22 |
[GO] |
2022―Jan―01 |
In vitro Potential Antiviral SARS-CoV-19- Activity of Natural Product Thymohydroquinone and Dithymoquinone from Nigela sativia |
Eman R. Esharkawy, Faisal Almalki, Taibi Ben Hadda |
23 |
[GO] |
2021―Dec―21 |
Virtual screening and in vitro validation of natural compound inhibitors against SARS-CoV-2 spike protein |
Helen Power, Jiadai Wu, Stuart Turville, Anupriya Aggarwal, Peter Valtchev, Aaron Schindeler, Fariba Dehghani |
24 |
[GO] |
2021―Oct―30 |
The Mpro structure-based modifications of ebselen derivatives for improved antiviral activity against SARS-CoV-2 virus |
Zhen Qiao, Ningning Wei, Lin Jin, Hongyi Zhang, Jiajie Luo, Yanru Zhang, KeWei Wang |
25 |
[GO] |
2021―Sep―23 |
A Robust High-throughput Fluorescent Polarization Assay for the Evaluation and Screening of SARS-CoV-2 Fusion Inhibitors |
Xinjian Yin, Litong Chen, Siwen Yuan, Lan Liu, Zhizeng Gao |
26 |
[GO] |
2021―Aug―28 |
Polyketone metabolites isolated from Rhodiola tibetica endohytic fungus Alternaria sp. HJT-Y7 and their SARS-CoV-2 virus inhibitory activitives |
Xuan Lu, Xiao-Yuan Tang, Hai-Xin Wang, Wei-jin Huang, Wei-Xing Feng, Bao-Min Feng |
27 |
[GO] |
2021―Aug―24 |
Synthesis of Novel Calcium Channel Blockers with ACE2 inhibition and dual antihypertensive /Anti-Inflammatory Effects: A possible Therapeutic tool for COVID-19 |
Shahenda Mahgoub, Mohamed-I Kotb El-Sayed, Mohamed F. El-Shehry, Samir Mohamed Awad, Yara E. Mansour, Samar S. Fatahala |
28 |
[GO] |
2021―Jul―05 |
Pomegranate Peel Extract Polyphenols Attenuate the SARS-CoV-2 S-glycoprotein Binding Ability to ACE2 Receptor: In Silico and In Vitro Studies |
Relja Suručić, Maja Travar, Miroslav Petković, Miloš P. Stojiljković, Milkica Grabež, Katarina Šavikin, et al. (+2) Gordana Zdunić, Ranko Škrbić |
29 |
[GO] |
2021―Jun―30 |
3-Alkenyl-2-oxindoles: Synthesis, antiproliferative and antiviral properties against SARS-CoV-2 |
Adel S. Girgis, Siva S. Panda, Aladdin M. Srour, Anwar Abdelnaser, Soad Nasr, Yassmin Moatasim, et al. (+11) Omnia Kutkat, Ahmed El Taweel, Ahmed Kandeil, Ahmed Mostafa, Mohamed A. Ali, Nehmedo G. Fawzy, Mohamed S. Bekheit, ElSayed M. Shalaby, Lara Gigli, Walid Fayad, Ahmed A. F. Soliman |
30 |
[GO] |
2021―Jun―23 |
New quinoline-triazole conjugates: Synthesis, and antiviral properties against SARS-CoV-2 |
Israa A. Seliem, Siva S. Panda, Adel S. Girgis, Yassmin Moatasim, Ahmed Kandeil, Ahmed Mostafa, et al. (+8) Mohamed A. Ali, Eman S. Nossier, Fatma Rasslan, Aladdin M Srour, Rajeev Sakhuja, Tarek S. Ibrahim, Zakaria K.M. Abdel-samii, Amany M.M. Al-Mahmoudy |
31 |
[GO] |
2021―May―25 |
Potential drug development and therapeutic approaches for clinical intervention in COVID-19 |
Jayanta Dowarah, Brilliant N. Marak, Umesh Chand Singh Yadav, Ved Prakash Singh |
32 |
[GO] |
2021―May―05 |
Synthesis, molecular docking, and in silico ADMET studies of 4-benzyl-1-(2,4,6-trimethyl-benzyl)-piperidine: Potential Inhibitor of SARS-CoV2 |
R. Nandini Asha, B. Ravindran Durai Nayagam, Nattamai Bhuvanesh |
33 |
[GO] |
2021―Apr―08 |
Ebsulfur and Ebselen as highly potent scaffolds for the development of potential SARS-CoV-2 antivirals |
Le-Yun Sun, Cheng Chen, Jianpeng Su, Jia-Qi Li, Zhihui Jiang, Han Gao, et al. (+4) Jia-Zhu Chigan, Huan-Huan Ding, Le Zhai, Ke-Wu Yang |
34 |
[GO] |
2021―Mar―30 |
Novel inhibitors of the main protease enzyme of SARS-CoV-2 identified via molecular dynamics simulation-guided in vitro assay |
Jennifer Loschwitz, Anna Jäckering, Monika Keutmann, Maryam Olagunju, Raphael J. Eberle, Monika Aparecida Coronado, et al. (+2) Olujide O. Olubiyi, Birgit Strodel |
35 |
[GO] |
2021―Feb―24 |
Discovery of Novel Inhibitors Against Main Protease (Mpro) of SARS-CoV-2 via Virtual Screening and Biochemical Evaluation |
Sheng Guo, Hang Xie, Yu Lei, Bin Liu, Li Zhang, Yechun Xu, Zhili Zuo |
36 |
[GO] |
2020―Nov―20 |
Computational Drug Discovery and Repurposing for the Treatment of COVID-19: A Systematic Review |
Kawthar Mohamed, Niloufar Yazdanpanah, Amene Saghazadeh, Nima Rezaei |
37 |
[GO] |
2020―Nov―20 |
Drug Repurposing for the Treatment of COVID-19: Pharmacological Aspects and Synthetic Approaches |
Pedro N. Batalha, Luana S.M. Forezi, Carolina G.S. Lima, Fernanda P. Pauli, Fernanda C.S. Boechat, Maria Cecília B.V. Souza, et al. (+3) Anna C. Cunha, Vitor F. Ferreira, Fernando C. Silva |
38 |
[GO] |
2020―Oct―28 |
Measurement of oxidized albumin: An opportunity for diagnoses or treatment of COVID-19 |
Nasim Rahmani-Kukia, Ardeshir Abbasi, Nafiseh Pakravan, Zuhair Mohammad Hassan |
39 |
[GO] |
2020―Oct―07 |
Nano-sized Formazan analogues: Synthesis, structure elucidation, antimicrobial activity and Docking study for COVID-19 |
Huda K. Mahmoud, Basim H. Asghar, Marwa F. Harras, Thoraya A. Farghaly |
40 |
[GO] |
2020―Sep―29 |
A Perspective on Potential Target Proteins of COVID-19: Comparison with SARS-CoV for Designing New Small Molecules |
Devendra Kumar, Gaurav Chauhan, Sourav Kalra, Bhupinder Kumar, Manjinder Singh Gill |
41 |
[GO] |
2020―Sep―24 |
Role of heterocyclic compounds in SARS and SARS CoV-2 pandemic |
Meenakshi Negi, Pooja A Chawla, Abdul Faruk, Viney Chawla |
42 |
[GO] |
2020―Sep―08 |
Druggable targets of SARS-CoV-2 and treatment opportunities for COVID-19 |
Banoth Karan Kumar, Kondapalli Venkata Gowri Chandra Sekhar, Selvaraj Kunjiappan, Joazaizulfazli Jamalis, Rafael Balaña-Fouce, Babu L. Tekwani, Murugesan Sankaranarayanan |
43 |
[GO] |
2020―Sep―02 |
Is Oseltamivir suitable for fighting against COVID-19: in silico assessment, in vitro and retrospective study |
Qi Tan, Limin Duan, YanLing Ma, Feng Wu, Qi Huang, Kaimin Mao, et al. (+13) Wenjing Xiao, Hui Xia, Shujing Zhang, E. Zhou, Pei Ma, Siwei Song, YuMei Li, Zilin Zhao, Yice Sun, Zeyu Li, Wei Geng, Zengrong Yin, Yang Jin |